Pyridylimine palladium(II) complexes: one-pot synthesis and monoamine oxidase inhibition

An efficient one-pot synthesis of the cis-pyridylimine palladium (II) complexes is reported. The compo- sition and structure were proved by NMR, IR, X-ray, elemental analysis. monoamine oxidase inhibition activity synthesized complexes, including six previously unknown, inves- tigated on native mouse brains. Some compounds: cis-dichlorido-2,6-dimethyl-N- ((pyridin-2-yl)methylene)anilinepalladium(II), cis-dichlorido-4-nitro-N-((pyridin-2-yl)methylene)- anilinepalladium(II), cis-dibromido-2,6-di(propan-2-yl)-N-((pyridin-2-yl)methylene)aniline- palladium(II) inhibited with moderate (IC50: 13.09–17.66 μМ). None studied compounds showed cytotoxic against HEK-293 cell line (human kidney embryonic cells). Acute systemic toxicity assay, that conducted intraperitoneal injection cis-dichlorido-4- nitro-N-((pyridin-2-yl)methylene)anilinepalladium(II) indicated low (LD50> 5000 mg / kg) for outbred stocks mice. Bioavailability was assessed logP’s measurement.